Tip of the Day!

Vampire Bats Take Bite Out Of Stroke!

Substance in Bat Saliva may Reduce Stroke Damage

By Jennifer Warner


Jan. 9, 2003 -- They may be best known for sucking blood, but vampire bats may hold the key to getting blood flowing smoothly again and preventing further brain damage after a stroke. Researchers say they've found a way to harness the clot-busting power of a substance found in the bats' saliva, and it may offer important advantages over currently available treatments. 


A new study found the substance, known as desmoteplase, or DSPA, can extend the treatment window after a stroke by up to three times longer than allowed by conventional medications -- without increasing the risk of additional brain damage.

 

The findings appear in the Jan. 10 issue of Stroke: Journal of the American Heart Association. 


Most strokes are caused by a blood clot or series of clots that prevents blood from reaching the brain. Researchers say DSPA helps destroy these clots by targeting fibrin, a protein in the blood that helps form blood clots. 


"When the vampire bat bites its victim, it secretes this powerful clot-dissolving (fibronolytic) substance so that the victim's blood will keep flowing, allowing the bat to feed," says researcher Robert Medcalf, PhD, senior research fellow at Monash University Department of Medicine at Box Hill Hospital in Victoria, Australia, in a news release. 


About 20 years ago researchers discovered that this vampire bat enzyme was genetically similar to a clot-busting substance known as tissue plasminogen activator (t-PA), but the bat enzyme was much more potent. 


Currently, an intravenous form of this medication (rt-PA) is FDA-approved for use only within three hours of the start of a stroke, because later use may increase the risk of bleeding in the brain. 


In the study, researchers injected either t-PA or DSPA into the brains of mice and monitored their brains for cell damage. They found that DSPA was able to zero in on fibrin without stimulating another system in the brain that promotes cell death, while the t-PA injection produced a toxic effect on brain cells and increased the amount of brain damage. 


It's this highly targeted action of DSPA that would allow it to be given later than t-PA without promoting brain cell death. 


But experts say this study only looked at potential health risks posed by using the substance in mice without stroke, and more studies are needed to determine if this approach actually improves stroke outcomes in humans. 


The researchers say DSPA is now being tested up to nine hours after the start of stroke in human clinical trials in Europe, Asia, and Australia, and a U.S. study may begin this year. 




SOURCE: Stroke: Journal of the American Heart Association, Jan. 10, 2003 • News release, American Heart Association.


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